High Containment Isolators

• Designed to safely handle potent compounds from OEB3 to OEB6
• Negative pressure cascade
• Single chamber design
• Material Pass Box, RTPs and Bag Out Systems
• Full ergonomic assessment
• Operational flexibility
• Designed for safe or hazardous area classification
• Safety features designed into the system including interlocks, purge systems and safe change systems
• CIP/WIP Capabilities
• PLC control system including interface with site networks
• Compliance with all appropriate design standards and guidelines

Operational flexibility

• Work area for installation of various laboratory or weighing equipment
• Integrated Power Sockets and Service outlets
• Off floor storage

Interlocked Pass Box

• Interlocked pass box to allow safe transfer of materials and tools during process operations

Wash in Place (WIP)

• Hand held wash hose providing manual cleaning of the chamber internals
• Spray balls are also available if required

Pharmaceutical Laboratory’s handle more potent materials during the early-stage development and in process testing of pharmaceutical compounds. Howorth UltraSAFE High Isolators are designed utilising our specialist experience including stringent safety measures to ensure protection of personnel and the environment.

Operational flexibility

• Work area for easy installation of various laboratory, process or weighing equipment
• Integrated Power Sockets and Service outlet
• Off floor storage
• Compact footprint

Wash In Place (WIP)

• Hand held wash hose providing manual cleaning of the chamber internals
• Spray balls are also available if required

Chemical Synthesis is a key stage of pharmaceutical manufacturing processes when creating complex chemical reactions in accordance with the drug formulation process. Howorth UltraSAFE Isolators are designed utilising our specialist experience including stringent safety measures to ensure protection of personnel and the environment.

Integrated solutions:

• Various Reaction, Mixing and Process systems including agitated and non-agitated designs
• Materials of construction including Hastelloy, Stainless Steel and Borosilicate Glass
• Product contact parts only integrated within the isolator chamber
• Agitated drives positioned external to the isolator chamber
• Pressurisation systems independent of the isolator
• Safety Interlocks
• WIP and Purge Systems

Dispensing of highly potent compounds is a critical stage of the pharmaceutical manufacturing process. Howorth UltraSAFE Isolators are designed utilising our specialist experience, including stringent safety measures, to ensure protection of personnel and the environment.

Integrated high-accuracy weighing systems:

• Compliant with the area classification and WIP requirements
• Internal operator display
• Internal push buttons to ensure accuracy is achieved during each dispensing process

Integrated product transfer systems: 

• Split butterfly valves Product transfer devices
• Output containers for downstream processes
• Manual and fully automated systems
• Stand-alone or fully integrated within a dedicated extracted chamber

Integrated material handling systems: 

• Drum docking hoists
• Donor drum systems providing flexibility to handle a variety of drum sizes and types
• Stand-alone or fully integrated within a dedicated extracted chamber
• Safe operation through the use of interlocks and light curtains

Sieving of Highly Potent compounds is a key stage of pharmaceutical manufacturing processes to reduce the particle sizes in accordance with the drug formulation process. Howorth UltraSAFE Isolators are designed utilising our specialist experience including stringent safety measures to ensure protection of personnel and the environment.

High accuracy weighing systems:

• Compliant with the are classification and WIP requirements
• Internal operator display
• Internal push buttons ensuring accuracy is achieved during each dispensing process

Integrated sieving solutions:

• Various sieving configurations including interchangeable sieve mesh.
• Product contact parts only integrated within the isolator chamber
• Combine with product control valves

Integrated materials handling systems:

• Drum docking hoists
• Donor drums providing flexibility to handle various drum sizes and types
• Stand alone or integrated within dedicated extracted chamber

Vacuum Drying of Highly Potent slurries is a key stage of pharmaceutical manufacturing processes to provide uniform drying at lower temperatures in accordance with the drug formulation process. Howorth UltraSAFE Isolators are designed utilising our specialist experience including stringent safety measures to ensure protection of personnel and the environment.

Integrated solutions:

• Various tray dryer configurations including single or double chamber designs and multiple units
• Materials of construction including Hastelloy and Stainless Steel
• Product contact parts only integrated within the isolator chamber
• Heat Transfer Units and Pipework
• Safety Interlocks
• WIP and Purge Systems

Milling of Highly Potent compounds is a key stage of pharmaceutical manufacturing processes to reduce the particle sizes in accordance with the drug formulation process. Howorth UltraSAFE Isolators are designed utilising our specialist experience including stringent safety measures to ensure protection of personnel and the environment.

High accuracy weighing systems:

• Compliant with the area classification and WIP requirements
• Internal operator display
• Internal push buttons ensuring accuracy is achieved during each dispensing process.

Integrated milling solutions:

• Various milling configurations including interchangeable solutions
• Product contact parts only integrated within the isolator chamber
• Combine with product control valves
• WIP and Purge systems

Integrated Materials handling systems:

• Drum docking hoists
• Donor drums providing flexibility to handle various drum sizes and types
• Stand alone or integrated within dedicated extracted chamber
• Safe operation including interlocks and light curtains